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The role of changes in maximum standardized uptake value of FDG PET-CT for post-treatment surveillance in patients with head and neck squamous cell carcinoma treated with chemoradiotherapy: preliminary findings.
- Source :
-
The British journal of radiology [Br J Radiol] 2017 Mar; Vol. 90 (1071), pp. 20150404. Date of Electronic Publication: 2017 Jan 05. - Publication Year :
- 2017
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Abstract
- Objective: No clear consensus exists regarding the optimal interval and frequency of follow-up positron emission tomography (PET)-CT in patients with head and neck squamous cell carcinoma (HNSCC) treated with chemoradiotherapy (CRT). Here, we sought to clarify whether the changes in the maximum standardized uptake value (ΔSUV <subscript>max</subscript> ) may be a valid parameter to help decision-making for surveillance management after CRT.<br />Methods: 40 patients underwent PET-CT at pre-treatment and 3 months after CRT. Patients were followed by sequential PET-CT for 2 years after CRT. The ΔSUV <subscript>max</subscript> of the primary tumour and the metastatic nodes were calculated between pre-treatment and 3 months after the CRT, and we evaluated the associations between ΔSUV <subscript>max</subscript> and the manifestation of recurrence, time to recurrence and the patient survival.<br />Results: The ΔSUV <subscript>max</subscript> of the primary tumour was significantly lower for the lesions with recurrence than that for those with non-recurrence for both the primary site and the nodal site (p = 0.007, 0.02). A significant correlation was found between the time to recurrence and the ΔSUV <subscript>max</subscript> of the primary tumour (r = 0.63, p < 0.05). The threshold ΔSUV <subscript>max</subscript> of the primary tumour of 1.04 revealed 76.9% sensitivity and 86.4% specificity for distinguishing recurrence from non-recurrence. The progression-free survival and overall survival of the two patient groups divided by the ΔSUV <subscript>max</subscript> of the primary tumour at 1.04 showed a significant difference (p = 0.003, 0.02). The ΔSUV <subscript>max</subscript> of the metastatic nodes did not show a significant association with recurrence or patient survival.<br />Conclusion: The ΔSUV <subscript>max</subscript> of the primary tumour showed a significant association with recurrence and patient survival. Advances in knowledge: The ΔSUV <subscript>max</subscript> of the primary tumour may be a valid clinical parameter to help decision-making for the surveillance management of patients with HNSCC after CRT.
- Subjects :
- Aged
Aged, 80 and over
Disease-Free Survival
Female
Humans
Male
Middle Aged
Prospective Studies
Squamous Cell Carcinoma of Head and Neck
Treatment Outcome
Carcinoma, Squamous Cell diagnostic imaging
Carcinoma, Squamous Cell therapy
Chemoradiotherapy methods
Fluorodeoxyglucose F18 pharmacokinetics
Head and Neck Neoplasms diagnostic imaging
Head and Neck Neoplasms therapy
Positron Emission Tomography Computed Tomography methods
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1748-880X
- Volume :
- 90
- Issue :
- 1071
- Database :
- MEDLINE
- Journal :
- The British journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 28055245
- Full Text :
- https://doi.org/10.1259/bjr.20150404