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Are pulmonary hemostasis and fibrinolysis out of balance in equine chronic pneumopathies?
- Source :
-
Journal of veterinary science [J Vet Sci] 2017 Sep 30; Vol. 18 (3), pp. 349-357. - Publication Year :
- 2017
-
Abstract
- Clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute-phase protein, and pulmonary hemostasis and fibrinolysis marker (fibrinogen, serum amyloid A [SAA], and D-dimer) results were compared between control and respiratory disease-affected horses. Using a clinical scoring system, horses (n = 58) were classified as respiratory disease-free (Controls, n = 15) or with recurrent airway obstruction (RAO; n = 18), inflammatory airway disease (n = 14) or chronic interstitial pneumopathy (n = 11). There were no significant differences in fibrinogen concentrations among groups, but there was a trend toward a lower value in controls (median 0.0024 g/L) than in horses with chronic pneumopathies (median 0.0052 g/L), in particular, those with RAO (median 0.0062 g/L). Fibrinogen concentration was positively correlated with percentage of neutrophils in BALF ( r <subscript>s</subscript> = 0.377, p = 0.004). SAA concentrations were low; 65.5% of samples were below the detection limit. D-dimer concentrations were also low and quantifiable concentrations were only obtained after ultrafiltration and only in RAO (median 0.1 mg/L). In conclusion, there was limited evidence of increased coagulatory activity in chronic pneumopathies, apart from RAO. It is uncertain whether fibrinogen and D-dimer concentrations increased due to their role as acute-phase proteins or as a misbalance of coagulation and fibrinolysis.
- Subjects :
- Acute-Phase Proteins analysis
Airway Obstruction metabolism
Airway Obstruction physiopathology
Airway Obstruction veterinary
Animals
Bronchoalveolar Lavage Fluid chemistry
Bronchoalveolar Lavage Fluid cytology
Fibrin Fibrinogen Degradation Products analysis
Fibrinogen analysis
Horse Diseases metabolism
Horses
Lung Diseases metabolism
Lung Diseases physiopathology
Serum Amyloid A Protein analysis
Fibrinolysis physiology
Hemostasis physiology
Horse Diseases physiopathology
Lung Diseases veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1976-555X
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of veterinary science
- Publication Type :
- Academic Journal
- Accession number :
- 28057902
- Full Text :
- https://doi.org/10.4142/jvs.2017.18.3.349