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Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study.
- Source :
-
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2017 May; Vol. 42 (6), pp. 1361-1370. Date of Electronic Publication: 2017 Jan 12. - Publication Year :
- 2017
-
Abstract
- Most individuals identified as ultra-high-risk (UHR) for psychosis do not develop frank psychosis. They continue to exhibit subthreshold symptoms, or go on to fully remit. Prior work has shown that the volume of CA1, a subfield of the hippocampus, is selectively reduced in the early stages of schizophrenia. Here we aimed to determine whether patterns of volume change of CA1 are different in UHR individuals who do or do not achieve symptomatic remission. Structural MRI scans were acquired at baseline and at 1-2 follow-up time points (at 12-month intervals) from 147 UHR and healthy control subjects. An automated method (based on an ex vivo atlas of ultra-high-resolution hippocampal tissue) was used to delineate the hippocampal subfields. Over time, a greater decline in bilateral CA1 subfield volumes was found in the subgroup of UHR subjects whose subthreshold symptoms persisted (n=40) and also those who developed clinical psychosis (n=12), compared with UHR subjects who remitted (n=41) and healthy controls (n=54). No baseline differences in volumes of the overall hippocampus or its subfields were found among the groups. Moreover, the rate of volume decline of CA1, but not of other hippocampal subfields, in the non-remitters was associated with increasing symptom severity over time. Thus, these findings indicate that there is deterioration of CA1 volume in persistently symptomatic UHR individuals in proportion to symptomatic progression.
- Subjects :
- Adolescent
Adult
CA1 Region, Hippocampal diagnostic imaging
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Psychotic Disorders diagnostic imaging
Risk
Severity of Illness Index
Young Adult
CA1 Region, Hippocampal pathology
Disease Progression
Prodromal Symptoms
Psychotic Disorders pathology
Psychotic Disorders physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1740-634X
- Volume :
- 42
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28079061
- Full Text :
- https://doi.org/10.1038/npp.2017.5