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Establishing the standard method of cochlear implant in Rongchang pig.

Authors :: Chen W
Yi H
Zhang L
Ji F
Yuan S
Zhang Y
Ren L
Li J
Chen L
Guo W
Yang S
Source :: Acta oto-laryngologica [Acta Otolaryngol] 2017 May; Vol. 137 (5), pp. 503-510. Date of Electronic Publication: 2017 Jan 12.
Publication Year :: 2017
Abstract: Conclusions: In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic.<br />Objective: The aim of this study was to establish a standard method of cochlear implant in a large mammal-pig.<br />Methods: Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf +/+) and mutation group with hearing loss (Mitf -/-). Cochlear implants were used and ABR and EABR were recorded. The implanted electrodes were observed by X-ray and HE stains.<br />Results: The success with cochlear implant and the best electrode position could be defined in all animals, the coiling of the cochlea reached 1.5-1.75 turns. Immediately after the operation of cochlear implants, the ABR threshold of the operated ear (right) could not be derived for each frequency at 120 dB SPL. Moreover, 7 days after surgery, the low-frequency ABR threshold of the operated ear (right) could be derived partly at 100 dB SPL, but the high-frequency ABR threshold could not be derived at 120 dB SPL. Immediately or 1 week after cochlear implants, the EABR threshold was 90 CL in the Mitf +/+ group. This was obviously lower than the 190 CL in the Mitf -/- group.