Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model.

Authors :: Pok S
Stupin IV
Tsao C
Pautler RG
Gao Y
Nieto RM
Tao ZW
Fraser CD Jr
Annapragada AV
Jacot JG
Source :: Advanced healthcare materials [Adv Healthc Mater] 2017 Mar; Vol. 6 (5). Date of Electronic Publication: 2017 Jan 12.
Publication Year :: 2017
Abstract: In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.<br /> (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Disease Models, Animal
Female
Male
Polyesters chemistry
Polyesters pharmacology
Rats
Rats, Sprague-Dawley
Chitosan chemistry
Chitosan pharmacology
Hydrogels chemistry
Hydrogels pharmacology
Materials Testing
Membranes, Artificial
Myocardium
Pericardium

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