PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.

Authors :: Fuchs A
Torroba M
Kinkley S
Source :: Transcription [Transcription] 2017 Mar 15; Vol. 8 (2), pp. 106-112. Date of Electronic Publication: 2017 Jan 19.
Publication Year :: 2017
Abstract: We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.

Subjects :: Animals
Chromatin metabolism
DNA-Binding Proteins genetics
Histone Methyltransferases
Histone-Lysine N-Methyltransferase metabolism
Histones metabolism
Humans
Mice
Polycomb-Group Proteins genetics
Polycomb-Group Proteins metabolism
Promoter Regions, Genetic
RNA Polymerase II genetics
RNA Splice Sites
Transcription Factors genetics
DNA-Binding Proteins metabolism
RNA Polymerase II metabolism
Transcription Factors metabolism
Transcription, Genetic physiology

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