Back to Search
Start Over
The Green Tea Catechin Epigallocatechin Gallate Ameliorates Graft-versus-Host Disease.
- Source :
-
PloS one [PLoS One] 2017 Jan 19; Vol. 12 (1), pp. e0169630. Date of Electronic Publication: 2017 Jan 19 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Allogeneic hematopoetic stem cell transplantation (allo-HSCT) is a standard treatment for leukemia and other hematologic malignancies. The major complication of allo-HSCT is graft-versus-host-disease (GVHD), a progressive inflammatory illness characterized by donor immune cells attacking the organs of the recipient. Current GVHD prevention and treatment strategies use immune suppressive drugs and/or anti-T cell reagents these can lead to increased risk of infections and tumor relapse. Recent research demonstrated that epigallocatechin gallate (EGCG), a component found in green tea leaves at a level of 25-35% at dry weight, may be useful in the inhibition of GVHD due to its immune modulatory, anti-oxidative and anti-angiogenic capacities. In murine allo-HSCT recipients treated with EGCG, we found significantly reduced GVHD scores, reduced target organ GVHD and improved survival. EGCG treated allo-HSCT recipients had significantly higher numbers of regulatory T cells in GVHD target organs and in the blood. Furthermore, EGCG treatment resulted in diminished oxidative stress indicated by significant changes of glutathione blood levels as well as glutathione peroxidase in the colon. In summary, our study provides novel evidence demonstrating that EGCG ameliorates lethal GVHD and reduces GVHD-related target organ damage. Possible mechanisms are increased regulatory T cell numbers and reduced oxidative stress.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Alkaloids administration & dosage
Allografts
Animals
Antioxidants pharmacology
Benzodioxoles administration & dosage
Catechin administration & dosage
Catechin blood
Catechin pharmacology
Disease Models, Animal
Female
Graft Survival drug effects
Graft vs Host Disease drug therapy
Graft vs Host Disease metabolism
Hematopoietic Stem Cell Transplantation adverse effects
Humans
Immunologic Factors pharmacology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Neovascularization, Pathologic prevention & control
Oxidative Stress drug effects
Piperidines administration & dosage
Polyunsaturated Alkamides administration & dosage
Quercetin administration & dosage
T-Lymphocytes, Regulatory drug effects
Tea chemistry
Catechin analogs & derivatives
Graft vs Host Disease prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 28103249
- Full Text :
- https://doi.org/10.1371/journal.pone.0169630