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Effects of Long-Term Water-Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2017 Jan 18; Vol. 18 (1). Date of Electronic Publication: 2017 Jan 18. - Publication Year :
- 2017
-
Abstract
- The aims of this study were to: (1) synthesize an anti-biofilm and protein-repellent dental composite by combining 2-methacryloyloxyethyl phosphorylcholine (MPC) with quaternary ammonium dimethylaminohexadecyl methacrylate (DMAHDM); and (2) evaluate the effects of water-aging for 180 days on protein resistance, bacteria-killing ability, and mechanical properties of MPC-DMAHDM composite. MPC and DMAHDM were added into a resin composite. Specimens were stored in distilled water at 37 °C for 1, 30, 90, and 180 days. Mechanical properties were measured in three-point flexure. Protein attachment onto the composite was evaluated by a micro bicinchoninic acid approach. An oral plaque microcosm biofilm model was employed to evaluate oral biofilm viability vs. water-aging time. Mechanical properties of the MPC-DMAHDM composite after 180-day immersion matched those of the commercial control composite. The composite with 3% MPC + 1.5% DMAHDM had much stronger resistance to protein adhesion than control ( p < 0.05). MPC + DMAHDM achieved much stronger biofilm-eradicating effects than MPC or DMAHDM alone ( p < 0.05). Biofilm colony-forming units on the 3% MPC + 1.5% DMAHDM composite were three orders of magnitude lower than commercial control. The protein-repellent and antibacterial effects were durable and showed no loss in water-aging from 1 to 180 days. The novel MPC-DMAHDM composite possessed strong and durable resistance to protein adhesion and potent bacteria-eradicating function, while matching the load-bearing ability of a commercial dental composite. The novel MPC-DMAHDM composite represents a promising means of suppressing oral plaque growth, acid production, and secondary caries.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Adsorption
Colony-Forming Units Assay
Lactic Acid metabolism
Methacrylates pharmacology
Microbial Viability drug effects
Phosphorylcholine analogs & derivatives
Phosphorylcholine pharmacology
Acrylic Resins pharmacology
Biofilms drug effects
Composite Resins pharmacology
Polyurethanes pharmacology
Proteins chemistry
Water pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28106774
- Full Text :
- https://doi.org/10.3390/ijms18010186