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Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.
- Source :
-
Nature [Nature] 1989 Nov 02; Vol. 342 (6245), pp. 45-50. - Publication Year :
- 1989
-
Abstract
- The Caenorhabditis elegans gene unc-22 encodes a very large muscle protein, called twitchin, which consists of a protein kinase domain and several copies of two short motifs. The sequence of twitchin has unexpected similarities to the sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules and vertebrate muscle proteins, including myosin light-chain kinase. These homologies, together with results from earlier genetic and molecular analyses, indicate that twitchin is involved in a novel mechanism of myosin regulation.
- Subjects :
- Amino Acid Sequence
Animals
Caenorhabditis metabolism
Genes
Molecular Sequence Data
Myosin-Light-Chain Kinase genetics
Restriction Mapping
Sequence Homology, Nucleic Acid
Caenorhabditis genetics
Caenorhabditis elegans Proteins
Calmodulin-Binding Proteins
Helminth Proteins genetics
Muscle Proteins genetics
Myosins metabolism
Protein Kinases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0028-0836
- Volume :
- 342
- Issue :
- 6245
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 2812002
- Full Text :
- https://doi.org/10.1038/342045a0