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Targeting a metabolic pathway to fight the flu.
- Source :
-
The FEBS journal [FEBS J] 2017 Jan; Vol. 284 (2), pp. 218-221. - Publication Year :
- 2017
-
Abstract
- Our antiviral arsenal to fight influenza viruses is limited and we need novel anti-flu drugs. Recently, cellular drug targets came into focus and omics analysis were instrumental to suggest candidate factors. In this issue of The FEBS Journal, Kainov and colleagues used transcriptome data to investigate virus-induced changes in tryptophan metabolism that may serve as immunomodulatory approach against viruses.<br /> (© 2017 Federation of European Biochemical Societies.)
- Subjects :
- Host-Pathogen Interactions
Humans
Indoleamine-Pyrrole 2,3,-Dioxygenase genetics
Indoleamine-Pyrrole 2,3,-Dioxygenase immunology
Influenza, Human immunology
Influenza, Human pathology
Influenza, Human virology
Interferons genetics
Interferons immunology
Kynurenine biosynthesis
Macrophages drug effects
Macrophages virology
Metabolic Networks and Pathways genetics
Metabolic Networks and Pathways immunology
Orthomyxoviridae genetics
Orthomyxoviridae growth & development
Transcriptome
Tryptophan metabolism
Antiviral Agents pharmacology
Immunologic Factors pharmacology
Influenza, Human drug therapy
Kynurenine antagonists & inhibitors
Metabolic Networks and Pathways drug effects
Orthomyxoviridae metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1742-4658
- Volume :
- 284
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The FEBS journal
- Publication Type :
- Academic Journal
- Accession number :
- 28121076
- Full Text :
- https://doi.org/10.1111/febs.13997