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DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data.
- Source :
-
Histopathology [Histopathology] 2017 Jun; Vol. 70 (7), pp. 1064-1071. Date of Electronic Publication: 2017 Mar 28. - Publication Year :
- 2017
-
Abstract
- Aims: Deleted in malignant brain tumours 1 (DMBT1) exerts functions in the regulation of epithelial differentiation and inflammation and has been proposed as a tumour suppressor. Because chronic inflammation is a hallmark of cholangiocarcinogenesis, the aim of this study was to investigate the expression of DMBT1 in biliary tract cancer (BTC) and to correlate this expression with clinicopathological data.<br />Methods and Results: The expression of DMBT1 protein was examined immunohistochemically in 157 BTC patients [41 intrahepatic (ICC), 60 extrahepatic cholangiocarcinomas (ECC) and 56 adenocarcinomas of the gallbladder (GBAC)]. Additionally, 56 samples of high-grade biliary intraepithelial neoplasia (BilIN 3) and 92 corresponding samples of histological non-neoplastic biliary tract tissues were included. DMBT1 expression was increased significantly in BilIN 3 compared to normal tissue (P < 0.0001) and BTC (P < 0.0001). BTC showed no significant difference in DMBT1 expression compared to non-neoplastic biliary tissue (P = 0.315). Absent DMBT1 expression in non-neoplastic biliary tissue of BTC patients was associated with poorer survival (P = 0.027). DMBT1 expression was correlated significantly with patients' age (P < 0.001).<br />Conclusion: DMBT1 is expressed differently in cholangiocarcinogenesis and poorer patients' survival rates are associated with absent DMBT1 expression in non-neoplastic biliary tissue, suggesting a tumour-suppressive role of DMBT1 in early cholangiocarcinogenesis.<br /> (© 2017 John Wiley & Sons Ltd.)
- Subjects :
- Adenocarcinoma metabolism
Adenocarcinoma mortality
Adenocarcinoma pathology
Aged
Bile Duct Neoplasms metabolism
Bile Duct Neoplasms mortality
Biliary Tract Neoplasms metabolism
Biliary Tract Neoplasms mortality
Calcium-Binding Proteins
Cholangiocarcinoma metabolism
Cholangiocarcinoma mortality
Cholangiocarcinoma pathology
Cohort Studies
DNA-Binding Proteins
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Proportional Hazards Models
Receptors, Cell Surface analysis
Tumor Suppressor Proteins
Bile Duct Neoplasms pathology
Biliary Tract Neoplasms pathology
Biomarkers, Tumor analysis
Receptors, Cell Surface biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2559
- Volume :
- 70
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 28130841
- Full Text :
- https://doi.org/10.1111/his.13175