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Detectability of colorectal neoplastic lesions using a novel endoscopic system with blue laser imaging: a multicenter randomized controlled trial.
- Source :
-
Gastrointestinal endoscopy [Gastrointest Endosc] 2017 Aug; Vol. 86 (2), pp. 386-394. Date of Electronic Publication: 2017 Jan 29. - Publication Year :
- 2017
-
Abstract
- Background and Aims: Most studies have not reported an improvement in the detection of adenomas with the use of image-enhanced colonoscopy methods, possibly because of the darkness of the images. To overcome this limitation, a new-generation endoscopic system has been developed. This system has 2 blue-laser imaging (BLI) observation modes. The BLI observation was set to BLI-bright mode to detect lesions. We aimed to evaluate the efficacy of BLI in detecting lesions.<br />Methods: This study was designed as a randomized controlled trial with participants from 8 institutions. We enrolled patients aged ≥40 years. The participants were randomly assigned to 2 groups: observation by using white-light imaging (WLI) with a conventional xenon light source (WLI group) or observation by using BLI-bright mode with a laser light source (BLI group). All of the detected lesions were resected or had a biopsy taken for histopathologic analysis. The primary outcome was the mean number of adenomas per patient (MAP) that were detected per procedure.<br />Results: The WLI and BLI groups consisted of 474 and 489 patients, respectively. The MAP was significantly higher in the BLI group than in the WLI group (mean ± standard deviation [SD] WLI 1.01 ± 1.36, BLI 1.27 ± 1.73; P = .008). Adenoma detection rate in the BLI group was not significantly higher than in the WLI group. Observation times differed significantly, with BLI (9.48 minutes) being longer than WLI (8.42; P < .001). The mean (± SD) number of polyps per patient was significantly higher in the BLI group compared with the WLI group (WLI 1.43 ± 1.64, BLI 1.84 ± 2.09; P = .001).<br />Conclusions: A newly developed system that uses BLI improves the detection of adenomatous lesions compared with WLI. (Clinical trial registration number: UMIN 000014555.).<br /> (Copyright © 2017. Published by Elsevier Inc.)
- Subjects :
- Adenoma pathology
Adenoma surgery
Aged
Biopsy
Colonoscopy methods
Color
Colorectal Neoplasms pathology
Colorectal Neoplasms surgery
Female
Humans
Male
Middle Aged
Adenoma diagnostic imaging
Colonic Polyps diagnostic imaging
Colonoscopy instrumentation
Colorectal Neoplasms diagnostic imaging
Lasers
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6779
- Volume :
- 86
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gastrointestinal endoscopy
- Publication Type :
- Academic Journal
- Accession number :
- 28147226
- Full Text :
- https://doi.org/10.1016/j.gie.2017.01.017