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The Role of Acid Suppression in Barrett's Esophagus.
- Source :
-
The American journal of medicine [Am J Med] 2017 May; Vol. 130 (5), pp. 525-529. Date of Electronic Publication: 2017 Feb 01. - Publication Year :
- 2017
-
Abstract
- In recent years, proton pump inhibitors (PPIs) have come under great scrutiny due to possible adverse, long-term side effects. At the same time, Barrett's esophagus, a premalignant condition in the esophagus, continues to be a disease whose course is thought to be improved by the use of PPIs. We review the impact of proton pump therapy on the esophagus and on Barrett's mucosa. In analyzing changes on a cellular level, we explore the effect of mixed gastric refluxate and the complex cascade that ensues with esophageal exposure of these contents. Because the incidence of esophageal adenocarcinoma is on the rise, we explore other factors that may contribute to the progression of Barrett's from non-dysplastic mucosa to esophageal adenocarcinoma. By revisiting the need for adequate acid suppression in Barrett's and increasing our understanding of other possible factors that may have an effect of Barrett's progression, we hope to support our multifaceted approach to acid suppression in patients with Barrett's esophagus.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adenocarcinoma prevention & control
Barrett Esophagus etiology
Barrett Esophagus physiopathology
Bile physiology
Disease Progression
Esophageal Mucosa drug effects
Esophageal Neoplasms prevention & control
Esophagus drug effects
Gastroesophageal Reflux physiopathology
Humans
Barrett Esophagus drug therapy
Proton Pump Inhibitors adverse effects
Proton Pump Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1555-7162
- Volume :
- 130
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28159599
- Full Text :
- https://doi.org/10.1016/j.amjmed.2016.12.032