Back to Search
Start Over
Phanerochaete sordida as a cause of pulmonary nodule in an immunocompromised patient: a case report.
Phanerochaete sordida as a cause of pulmonary nodule in an immunocompromised patient: a case report.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2017 Feb 10; Vol. 17 (1), pp. 135. Date of Electronic Publication: 2017 Feb 10. - Publication Year :
- 2017
-
Abstract
- Background: Phanerochaete sordida is a species of wood rotting fungus, which can degrade lignin, cellulose and hemicellulose contained in wood and other hard-to-biodegrade organic substances. However, to date, there have been no other reports demonstrating that P. sordida can infect humans.<br />Case Presentation: A 66-year-old Japanese man presented for a mass increasing in size on his left thigh. He had been suffering from rheumatoid arthritis for 18 years and chronic obstructive pulmonary disease for 20 years, for which he was being treated with 5 mg/day prednisolone and 8 mg/week methotrexate. The mass resection was performed two months later, and was diagnosed as malignant fibrous histiocytosis. However, a computed tomography examination for tumor recurrence after surgery showed a newly emergent pulmonary nodule. We therefore decided to resect the nodule by thoracoscopic procedure. Histopathological examination of the excised specimen showed that the lesion was a granuloma, with necrotic tissue and clumping of Aspergillus-like hyphae. Therefore, the nodule was diagnosed as a fungal infection and tissue specimens were cultured microbiologically. However, fungal growth was not observed. We consequently performed genetic analysis using a broad-range polymerase chain reaction. The 28S rRNA sequence demonstrated 100% homology with P. sordida using the NCBI BLAST program against the GenBank DNA databases.<br />Conclusions: Using broad-range polymerase chain reaction, we identified P. sordida as the causative agent of a pulmonary nodule. These findings indicate that P. sordida may be an additional opportunistic causative organism of pulmonary infection in immunocompromised patients.
- Subjects :
- Aged
Arthritis, Rheumatoid
DNA, Fungal analysis
Diagnosis, Differential
Humans
Lung Diseases, Fungal diagnostic imaging
Lung Diseases, Fungal microbiology
Lung Diseases, Fungal surgery
Male
Phanerochaete genetics
Polymerase Chain Reaction
Pulmonary Disease, Chronic Obstructive
Immunocompromised Host
Lung Diseases, Fungal diagnosis
Phanerochaete isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28183273
- Full Text :
- https://doi.org/10.1186/s12879-017-2244-9