A case report of rare palmoplantar keratosis and nail dystrophy with imatinib.

Authors :: Benabbes M
Tazi Mezalek Z
Meddah B
Source :: Annales pharmaceutiques francaises [Ann Pharm Fr] 2017 May; Vol. 75 (3), pp. 172-175. Date of Electronic Publication: 2017 Feb 09.
Publication Year :: 2017
Abstract: A 48-year-old woman developed palmoplantar hyperkeratosis during treatment with imatinib (400mg/day) for treatment of chronic myeloid leukemia. After 5months of treatment, she developed plantar lesions with yellow-brownish plaques and palmar desquamations. The skin biopsy has eliminated psoriasis. Imatinib was discontinued, and treatment with an emollient balm and a soothing repair cream with an improvement of symptoms. A French imputability assessment score of I3 was obtained, indicating a probable relationship between the side effect and imatinib. In our case, the skin adverse events require definitive drug discontinuation and change of treatment.<br /> (Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.)