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B cell activating factor (BAFF) selects IL-10 - B cells over IL-10 + B cells during inflammatory responses.
- Source :
-
Molecular immunology [Mol Immunol] 2017 May; Vol. 85, pp. 18-26. Date of Electronic Publication: 2017 Feb 12. - Publication Year :
- 2017
-
Abstract
- B cell activating factor (BAFF) regulates B cell maturation, survival, function, and plays a critical pathogenic role in autoimmune diseases. It remains unclear how BAFF affects IL-10 <superscript>-</superscript> B cells versus regulatory B cells (Bregs) in inflammatory responses. In this study, we found that IL-10-expressing Bregs decreased in lupus-prone MRL/lpr mice and experimental allergic encephalomyelitis (EAE) mice. On blockade of the effects of BAFF with TACI-IgG, IL-10 <superscript>+</superscript> Bregs were upregulated in MRL/lpr and EAE mice. In addition, BAFF expanded IL-10 <superscript>+</superscript> B cells over IL-10 <superscript>-</superscript> B cells under noninflammatory conditions in vitro, whereas it expanded IL-10 <superscript>-</superscript> B cells over IL-10 <superscript>+</superscript> B cells during inflammatory responses, such as stimulation with autoantigen and LPS. Finally, the selection of IL-10 <superscript>-</superscript> B cells over IL-10 <superscript>+</superscript> B cells by BAFF was dependent on BAFF receptors (BAFFR, TACI, and BCMA) that were upregulated by inflammatory responses. This study suggests that BAFF selects IL-10 <superscript>-</superscript> B cells over IL-10 <superscript>+</superscript> regulatory B cells via BAFF receptors in inflammatory responses.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Interleukin-10 immunology
Mice
Mice, Inbred C57BL
Mice, Inbred MRL lpr
B-Cell Activating Factor immunology
B-Lymphocyte Subsets immunology
Encephalomyelitis, Autoimmune, Experimental immunology
Inflammation immunology
Lupus Erythematosus, Systemic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 85
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28199852
- Full Text :
- https://doi.org/10.1016/j.molimm.2017.02.002