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Surgery and electrochemotherapy treatment of incompletely excised mammary carcinoma in two male pet rats (Rattus norvegicus).

Authors :
Lanza A
Pettorali M
Baldi A
Spugnini EP
Source :
The Journal of veterinary medical science [J Vet Med Sci] 2017 Mar 23; Vol. 79 (3), pp. 623-625. Date of Electronic Publication: 2017 Feb 18.
Publication Year :
2017

Abstract

Two male rats (Rattus norvegicus; 18 and 24 months old), were referred for treatment of large masses located in the axillary area. Following total body radiography and hematological and serum biochemical analysis, the rats were anesthetized, and the masses were surgically removed. Both lesions were diagnosed as mammary carcinoma based on histopathological diagnosis. The tumor beds were treated with two sessions of electrochemotherapy (ECT), two weeks apart. ECT involved cisplatin administration in the tumor bed, followed by a series of eight biphasic electric pulses. The treatment was well tolerated, and the rats were disease-free after 10 and 14 months. Therefore, adjuvant ECT resulted in good local control of mammary carcinoma and can potentially be used for adjuvant treatment of pet rats with cutaneous and adnexal tumors.

Details

Language :
English
ISSN :
1347-7439
Volume :
79
Issue :
3
Database :
MEDLINE
Journal :
The Journal of veterinary medical science
Publication Type :
Academic Journal
Accession number :
28216544
Full Text :
https://doi.org/10.1292/jvms.16-0578