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Retrobulbar ocular blood flow changes measured by colour Doppler imaging after intra-arterial chemotherapy in retinoblastoma.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2017 Oct; Vol. 101 (10), pp. 1419-1422. Date of Electronic Publication: 2017 Feb 22. - Publication Year :
- 2017
-
Abstract
- Purpose: To evaluate the effects of intra-arterial chemotherapy on retrobulbar blood flow parameters in patients with retinoblastoma.<br />Methods: 20 eyes of 10 patients with unilateral retinoblastoma that were treated with intra-arterial chemotherapy were evaluated using colour Doppler imaging. The peak systolic and end-diastolic velocities of the ophthalmic, central retinal and posterior ciliary arteries were determined. The pulsatility and resistance indices were calculated automatically. The treated eye was compared with the untreated (control) eye and with itself before and after intra-arterial chemotherapy.<br />Results: When comparing the retinoblastoma-containing eyes with the contralateral normal eyes, the peak systolic and end-diastolic velocities of the central retinal artery were significantly higher in the tumorous eyes than in the normal eyes before intra-arterial chemotherapy. Moreover, the peak systolic and end-diastolic velocities in the posterior ciliary and central retinal arteries were significantly decreased after intra-arterial chemotherapy in the tumorous eyes (p<0.05). There were no statistically significant differences in the other parameters.<br />Conclusions: Our results suggest that intra-arterial chemotherapy has a measurable effect on the retrobulbar blood flow, which can cause a decrease in the peak systolic and end-diastolic velocities in the posterior ciliary and central retinal arteries.<br />Competing Interests: Competing interests: None declared.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
- Subjects :
- Blood Flow Velocity
Carboplatin administration & dosage
Child, Preschool
Ciliary Arteries drug effects
Ciliary Arteries physiology
Echocardiography, Doppler, Color
Female
Humans
Infant
Infusions, Intra-Arterial
Male
Melphalan administration & dosage
Ophthalmic Artery physiology
Pulsatile Flow physiology
Regional Blood Flow physiology
Retinal Artery drug effects
Retinal Artery physiology
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Orbit blood supply
Regional Blood Flow drug effects
Retinal Neoplasms drug therapy
Retinal Neoplasms physiopathology
Retinoblastoma drug therapy
Retinoblastoma physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 101
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 28228407
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2016-310056