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Alzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design.

Authors :: de Wilde A
van Maurik IS
Kunneman M
Bouwman F
Zwan M
Willemse EA
Biessels GJ
Minkman M
Pel R
Schoonenboom NS
Smets EM
Wattjes MP
Barkhof F
Stephens A
van Lier EJ
Batrla-Utermann R
Scheltens P
Teunissen CE
van Berckel BN
van der Flier WM
Source :: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2017 Jan 23; Vol. 6, pp. 143-151. Date of Electronic Publication: 2017 Jan 23 (Print Publication: 2017).
Publication Year :: 2017
Abstract: Introduction: The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests (magnetic resonance imaging [MRI], cerebrospinal fluid [CSF], and amyloid positron emission tomography [PET]) to daily clinical practice with a focus on mild cognitive impairment (MCI).<br />Methods: ABIDE is a 3-year project with a multifaceted design and is structured into interconnected substudies using both quantitative and qualitative research methods.<br />Results: Based on retrospective data, we develop personalized risk estimates for MCI patients. Prospectively, we collect MRI and CSF data from 200 patients from local memory clinics and amyloid PET from 500 patients in a tertiary setting, to optimize application of these tests in daily practice. Furthermore, ABIDE will develop strategies for optimal patient-clinician conversations.<br />Discussion: Ultimately, this will result in a set of practical tools for clinicians to support the choice of diagnostic tests and facilitate the interpretation and communication of their results.