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Sertraline, a selective inhibitor of serotonin uptake, induces subsensitivity of beta-adrenoceptor system of rat brain.

Authors :
Koe BK
Koch SW
Lebel LA
Minor KW
Page MG
Source :
European journal of pharmacology [Eur J Pharmacol] 1987 Sep 11; Vol. 141 (2), pp. 187-94.
Publication Year :
1987

Abstract

Subacute administration (b.i.d. for 4 days) of sertraline, a potent and selective inhibitor of serotonin uptake, was found to reduce cyclic AMP generation by the norepinephrine receptor-coupled adenylate cyclase in rat limbic forebrain slices and decrease the number of beta-adrenoceptors in rat cerebral cortex without affecting the affinity of [3H]dihydroalprenolol binding. Co-administration of sertraline and the serotonin agonist, quipazine, at doses at which neither agent had an effect, resulted in desensitization of norepinephrine receptor-coupled adenylate cyclase and down-regulation of beta-adrenoceptors. These findings suggest that increased serotonergic activity may be involved in the induction of subsensitivity of the beta-adrenoceptor system of rat brain by sertraline.

Details

Language :
English
ISSN :
0014-2999
Volume :
141
Issue :
2
Database :
MEDLINE
Journal :
European journal of pharmacology
Publication Type :
Academic Journal
Accession number :
2824215
Full Text :
https://doi.org/10.1016/0014-2999(87)90262-7