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[Assessment of hematopoiesis and cytogenetics changes in interventional radiologists].
- Source :
-
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2016 May 25; Vol. 45 (6), pp. 626-630. - Publication Year :
- 2016
-
Abstract
- Objective: To investigate hematopoiesis and cytogenetics changes in staff of interventional radiology. Methods: A total of 121 intervention radiation workers, 245 common radiation workers and 100 medical personnel (healthy control) without exposure to radiation were enrolled in the study. The peripheral lymphocyte chromosomal aberrations and micronucleus were detected, and the result of white blood cells examination was analyzed. Results: Compared with common radiation group and healthy control group, decreases in white blood cells count, neutrophil ratio, and increase in lymphocyte ratio were observed in intervention radiation group (all P <0.05). Intervention radiation group had higher chromosome aberration rate and micronuclear rate than common radiation group and healthy control group (all P <0.05). Most common chromosome aberrations were dicentric chromosome, acentric ring, fragments and minute chromosome. Abnormal rates in chromosome aberration and micronucleus rates were increased with the rise of length of service, but no statistically significant difference was observed ( P >0.05). Conclusion: Long term exposure to ionizing radiation may lead to changes in the human hematopoietic system and cause human chromosome aberration, and the severity of such injuries may be associated with the dose of ionizing radiation.
- Subjects :
- Adult
Dose-Response Relationship, Radiation
Female
Humans
Male
Radiation Exposure statistics & numerical data
Radiation, Ionizing
Time Factors
Chromosome Aberrations radiation effects
Hematopoiesis radiation effects
Leukocyte Count statistics & numerical data
Leukocytes pathology
Leukocytes radiation effects
Lymphocytes pathology
Lymphocytes radiation effects
Lymphocytes ultrastructure
Micronuclei, Chromosome-Defective radiation effects
Occupational Exposure adverse effects
Radiation Exposure adverse effects
Radiologists statistics & numerical data
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1008-9292
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28247607
- Full Text :
- https://doi.org/10.3785/j.issn.1008-9292.2016.11.11