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Cyclotides as drug design scaffolds.

Authors :
Craik DJ
Du J
Source :
Current opinion in chemical biology [Curr Opin Chem Biol] 2017 Jun; Vol. 38, pp. 8-16. Date of Electronic Publication: 2017 Feb 27.
Publication Year :
2017

Abstract

Cyclotides are ultra-stable peptides derived from plants. They are around 30 amino acids in size and are characterized by their head-to-tail cyclic backbone and cystine knot. Their exceptional stability and tolerance to sequence substitutions has led to their use as frameworks in drug design. This article describes recent developments in this field, particularly developments over the last two years relating to the grafting of bioactive peptide sequences into the cyclic cystine knot framework of cyclotides to stabilize the sequences. Grafted cyclotides have now been developed that interact with protein or enzyme targets, both extracellular and intracellular, as well as with cell surface receptors and membranes.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-0402
Volume :
38
Database :
MEDLINE
Journal :
Current opinion in chemical biology
Publication Type :
Academic Journal
Accession number :
28249194
Full Text :
https://doi.org/10.1016/j.cbpa.2017.01.018