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Effects of Aspirin and Intrauterine Balloon on Endometrial Repair and Reproductive Prognosis in Patients with Severe Intrauterine Adhesion: A Prospective Cohort Study.
- Source :
-
BioMed research international [Biomed Res Int] 2017; Vol. 2017, pp. 8526104. Date of Electronic Publication: 2017 Jan 30. - Publication Year :
- 2017
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Abstract
- This study aimed to investigate the effects of estrogen in combination with aspirin and intrauterine balloon on the uterine endometrial repair and reproductive prognosis in patients after surgery for severe intrauterine adhesion (sIUA). We prospectively recruited 114 patients with sIUA. Intrauterine device (IUD) was placed and oral estrogen was administered after surgery. Patients were divided into control group and aspirin group. In addition, patients in aspirin group were subdivided into nonballoon group and balloon group. Results showed that, after therapy, the increase in endometrial thickness of aspirin groups was superior to control group ( P < 0.05). The scores of intrauterine adhesion and menstruation were significantly improved in balloon group as compared to nonballoon group and control group, and significant differences were also observed between nonballoon group and control group ( P < 0.05). Of 97 patients, 44.3% became pregnant after surgery, the live birth rate was 27.8%, and the miscarriage rate was 37.2%, but there were no significant differences among three groups ( P > 0.05). Thus, aspirin may promote the uterine endometrial growth and repair after surgery for sIUA, and IUD in combination with intrauterine balloon may reduce the recurrence of intrauterine adhesion, but their effect on the reproductive prognosis is required to be further studied.<br />Competing Interests: The authors declare that they have no competing interests.
- Subjects :
- Adult
Aspirin pharmacology
Endometrium diagnostic imaging
Endometrium physiopathology
Endometrium surgery
Female
Humans
Hysteroscopy
Menstruation drug effects
Postoperative Care
Pregnancy
Prognosis
Prospective Studies
Tissue Adhesions pathology
Tissue Adhesions physiopathology
Tissue Adhesions surgery
Uterine Diseases pathology
Uterine Diseases physiopathology
Aspirin therapeutic use
Endometrium pathology
Reproduction drug effects
Tissue Adhesions drug therapy
Uterine Balloon Tamponade
Uterine Diseases drug therapy
Uterine Diseases surgery
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2017
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 28251159
- Full Text :
- https://doi.org/10.1155/2017/8526104