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Radiological Analysis of Unused Donor Lungs: A Tool to Improve Donor Acceptance for Transplantation?
Radiological Analysis of Unused Donor Lungs: A Tool to Improve Donor Acceptance for Transplantation?
- Source :
-
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2017 Jul; Vol. 17 (7), pp. 1912-1921. Date of Electronic Publication: 2017 Mar 30. - Publication Year :
- 2017
-
Abstract
- Despite donor organ shortage, a large proportion of possible donor lungs are declined for transplantation. Criteria for accepting/declining lungs remain controversial because of the lack of adequate tools to aid in decision-making. We collected, air-inflated, and froze a large series of declined/unused donor lungs and subjected these lung specimens to CT examination. Affected target regions were scanned by using micro-CT. Lungs from 28 donors were collected. Two lungs were unused, six were declined for non-allograft-related reasons (collectively denominated nonallograft declines, n = 8), and 20 were declined because of allograft-related reasons. CT scanning demonstrated normal lung parenchyma in only four of eight nonallograft declines, while relatively normal parenchyma was found in 12 of 20 allograft-related declines. CT and micro-CT examinations confirmed the reason for decline in most lungs and revealed unexpected (unknown from clinical files or physical inspection) CT abnormalities in other lungs. CT-based measurements showed a higher mass and density in the lungs with CT alterations compared with lungs without CT abnormalities. CT could aid in the decision-making to accept or decline donor lungs which could lead to an increase in the quantity and quality of lung allografts.<br /> (© 2017 The American Society of Transplantation and the American Society of Transplant Surgeons.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Lung diagnostic imaging
Male
Middle Aged
Retrospective Studies
Tissue and Organ Procurement
Young Adult
Decision Making
Lung physiopathology
Lung Transplantation statistics & numerical data
Resource Allocation
Tissue Donors supply & distribution
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1600-6143
- Volume :
- 17
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
- Publication Type :
- Academic Journal
- Accession number :
- 28251829
- Full Text :
- https://doi.org/10.1111/ajt.14255