Back to Search Start Over

Radiological Analysis of Unused Donor Lungs: A Tool to Improve Donor Acceptance for Transplantation?

Radiological Analysis of Unused Donor Lungs: A Tool to Improve Donor Acceptance for Transplantation?

Authors :
Verleden SE
Martens A
Ordies S
Heigl T
Bellon H
Vandermeulen E
Van Herck A
Sacreas A
Verschakelen J
Coudyzer W
Van Raemdonck DE
Vos R
Weynand B
Verleden GM
Vanaudenaerde B
Neyrinck A
Source :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2017 Jul; Vol. 17 (7), pp. 1912-1921. Date of Electronic Publication: 2017 Mar 30.
Publication Year :
2017

Abstract

Despite donor organ shortage, a large proportion of possible donor lungs are declined for transplantation. Criteria for accepting/declining lungs remain controversial because of the lack of adequate tools to aid in decision-making. We collected, air-inflated, and froze a large series of declined/unused donor lungs and subjected these lung specimens to CT examination. Affected target regions were scanned by using micro-CT. Lungs from 28 donors were collected. Two lungs were unused, six were declined for non-allograft-related reasons (collectively denominated nonallograft declines, n = 8), and 20 were declined because of allograft-related reasons. CT scanning demonstrated normal lung parenchyma in only four of eight nonallograft declines, while relatively normal parenchyma was found in 12 of 20 allograft-related declines. CT and micro-CT examinations confirmed the reason for decline in most lungs and revealed unexpected (unknown from clinical files or physical inspection) CT abnormalities in other lungs. CT-based measurements showed a higher mass and density in the lungs with CT alterations compared with lungs without CT abnormalities. CT could aid in the decision-making to accept or decline donor lungs which could lead to an increase in the quantity and quality of lung allografts.<br /> (© 2017 The American Society of Transplantation and the American Society of Transplant Surgeons.)

Details

Language :
English
ISSN :
1600-6143
Volume :
17
Issue :
7
Database :
MEDLINE
Journal :
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Publication Type :
Academic Journal
Accession number :
28251829
Full Text :
https://doi.org/10.1111/ajt.14255