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Modality-specific target definition for laryngeal and hypopharyngeal cancer on FDG-PET, CT and MRI.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2017 Apr; Vol. 123 (1), pp. 63-70. Date of Electronic Publication: 2017 Mar 01. - Publication Year :
- 2017
-
Abstract
- Background and Purpose: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET.<br />Material and Methods: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumor <subscript>HE</subscript> ). The GTVs on CT and MRI were delineated in consensus. PET-based GTVs were automatically segmented. The three-dimensionally reconstructed specimen was registered to the various images. Modality-specific CTV margins were derived and added to the GTVs to achieve adequate tumor coverage. The resulting CTVs were compared with each other, to tumor <subscript>HE</subscript> , and to CTV <subscript>CT10</subscript> constructed on CT with the clinical margin of 10mm.<br />Results: CTV margins of 4.3mm (CT), 6.1mm (MRI) and 5.2mm (PET) were needed to achieve adequate tumor coverage. The median volumes of the resulting modality-specific CTVs were 44ml (CT), 48ml (MRI) and 39ml (PET), while the CTV <subscript>10mm</subscript> was 80ml.<br />Conclusion: For laryngohypopharyngeal tumors, 45-52% target volume reduction compared with CTV <subscript>10mm</subscript> is achievable when modality-specific CTV margins are used. PET-based CTVs were significantly smaller compared to CT- and MRI-based CTVs.<br /> (Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Female
Humans
Hypopharyngeal Neoplasms pathology
Hypopharyngeal Neoplasms surgery
Hypopharynx diagnostic imaging
Hypopharynx pathology
Hypopharynx surgery
Imaging, Three-Dimensional methods
Laryngeal Neoplasms pathology
Laryngeal Neoplasms surgery
Laryngectomy
Larynx diagnostic imaging
Larynx pathology
Larynx surgery
Male
Middle Aged
Preoperative Care methods
Radiopharmaceuticals
Fluorodeoxyglucose F18
Hypopharyngeal Neoplasms diagnostic imaging
Laryngeal Neoplasms diagnostic imaging
Magnetic Resonance Imaging methods
Positron-Emission Tomography methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 123
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28259450
- Full Text :
- https://doi.org/10.1016/j.radonc.2017.02.005