Back to Search
Start Over
Outcome of Kidney Transplant in Patients with Polycystic Kidney Disease: A Single-Center Study in Tunisia.
- Source :
-
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2017 Feb; Vol. 15 (Suppl 1), pp. 196-199. - Publication Year :
- 2017
-
Abstract
- Objectives: Autosomal dominant polycystic kidney disease is a common cause of end-stage renal disease and a common indication for renal transplant. This study was undertaken to evaluate the demographics, outcomes, and complications of renal transplant in patients with autosomal dominant polycystic kidney disease compared with other nephropathies.<br />Materials and Methods: In a retrospective case-control design, we reviewed the records of 7 patients with autosomal dominant polycystic kidney disease from a total of 701 renal transplant patients over a 30-year period (1986-2016). For each patient, a matched control was selected based on sex, age, year of transplant, and type of kidney donor. We excluded patients who underwent kidney transplant abroad and those with a follow-up period of less than 2 years.<br />Results: The number of patients with autosomal dominant polycystic kidney disease requiring transplant at our center was estimated at 0.23 per year, and the condition represented 1.57% of initial nephropathy causes. The mean patient age at transplant was 50.8 ± 8.05 years. There were 5 male and 2 female patients in the case group, with a male-to-female ratio of 2.5. The source of the graft was predominantly a living related donor (5/7). Four patients had extrarenal manifestations, the most common of which were liver cysts (3 patients). Rejection occurred in a single study patient (14.2%) and in 4 control patients (57.1%; P = .51). Two patients did not develop any complications. Complications noted after transplant included infection (3/7 cases vs 2/7 controls; P= .67) and cerebrovascular accidents (2/7 cases vs 0/7 controls).<br />Conclusions: Further studies with longer follow-up and greater numbers of patients are needed to compare more precisely the complications and results of transplant between patients with autosomal dominant polycystic kidney disease and other kidney transplant recipients.
- Subjects :
- Adult
Communicable Diseases etiology
Female
Graft Rejection etiology
Humans
Kidney Failure, Chronic diagnosis
Kidney Failure, Chronic etiology
Living Donors
Male
Middle Aged
Polycystic Kidney, Autosomal Dominant complications
Polycystic Kidney, Autosomal Dominant diagnosis
Retrospective Studies
Risk Factors
Stroke etiology
Time Factors
Treatment Outcome
Tunisia
Kidney Failure, Chronic surgery
Kidney Transplantation adverse effects
Polycystic Kidney, Autosomal Dominant surgery
Subjects
Details
- Language :
- English
- ISSN :
- 2146-8427
- Volume :
- 15
- Issue :
- Suppl 1
- Database :
- MEDLINE
- Journal :
- Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 28260467
- Full Text :
- https://doi.org/10.6002/ect.mesot2016.P78