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[Effect of guar on plasma lipids and on the biological activity of insulin in patients with type 2 diabetes mellitus].

Authors :
Casimirri F
Pasquali R
Melchionda N
Biso P
Capelli M
Martelli E
Source :
Minerva medica [Minerva Med] 1987 Dec 15; Vol. 78 (23), pp. 1753-7.
Publication Year :
1987

Abstract

10 patients with type 2 diabetes mellitus, in stable weight and diet therapy, followed a 2 months nutritional supplementation with guar, 15 g/day. Their previous nutritional and pharmacological therapy was not modified throughout the study. No changes occurred in body weight or major parameters of metabolic control. However, a significant fall occurred in fasting plasma, total and LDL cholesterol, and apolipoprotein B concentrations. Insulin sensitivity, measured by the "steady state plasma glucose", obtained after a 150 min glucose-insulin-somatostatin infusion, improved in all patients but two. A significant correlation was observed between steady state plasma glucose variations, the glycosylated haemoglobin A1c (r = 0.70; p less than 0.005), total (r = 0.77; p less than 0.001), and LDL cholesterol (r = 0.69; p less than 0.005) and apolipoprotein B concentrations (r = 0.75; p less than 0.005).

Details

Language :
Italian
ISSN :
0026-4806
Volume :
78
Issue :
23
Database :
MEDLINE
Journal :
Minerva medica
Publication Type :
Academic Journal
Accession number :
2827061