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[Effect of guar on plasma lipids and on the biological activity of insulin in patients with type 2 diabetes mellitus].
- Source :
-
Minerva medica [Minerva Med] 1987 Dec 15; Vol. 78 (23), pp. 1753-7. - Publication Year :
- 1987
-
Abstract
- 10 patients with type 2 diabetes mellitus, in stable weight and diet therapy, followed a 2 months nutritional supplementation with guar, 15 g/day. Their previous nutritional and pharmacological therapy was not modified throughout the study. No changes occurred in body weight or major parameters of metabolic control. However, a significant fall occurred in fasting plasma, total and LDL cholesterol, and apolipoprotein B concentrations. Insulin sensitivity, measured by the "steady state plasma glucose", obtained after a 150 min glucose-insulin-somatostatin infusion, improved in all patients but two. A significant correlation was observed between steady state plasma glucose variations, the glycosylated haemoglobin A1c (r = 0.70; p less than 0.005), total (r = 0.77; p less than 0.001), and LDL cholesterol (r = 0.69; p less than 0.005) and apolipoprotein B concentrations (r = 0.75; p less than 0.005).
- Subjects :
- Adult
Aged
Blood Glucose metabolism
Diabetes Mellitus, Type 2 drug therapy
Female
Glycated Hemoglobin metabolism
Humans
Insulin blood
Male
Middle Aged
Plant Gums
Diabetes Mellitus, Type 2 blood
Dietary Fiber pharmacology
Galactans pharmacology
Insulin therapeutic use
Lipids blood
Mannans pharmacology
Subjects
Details
- Language :
- Italian
- ISSN :
- 0026-4806
- Volume :
- 78
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Minerva medica
- Publication Type :
- Academic Journal
- Accession number :
- 2827061