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Immunoglobulin GM and KM genes and measles vaccine-induced humoral immunity.
- Source :
-
Vaccine [Vaccine] 2017 Oct 04; Vol. 35 (41), pp. 5444-5447. Date of Electronic Publication: 2017 Mar 06. - Publication Year :
- 2017
-
Abstract
- Identifying genetic polymorphisms that explain variations in humoral immunity to live measles virus vaccine is of great interest. Immunoglobulin GM (heavy chain) and KM (light chain) allotypes are genetic markers known to be associated with susceptibility to several infectious diseases. We assessed associations between GM and KM genotypes and measles vaccine humoral immunity (neutralizing antibody titers) in a combined cohort (n=1796) of racially diverse healthy individuals (age 18-41years). We did not discover any significant associations between GM and/or KM genotypes and measles vaccine-induced neutralizing antibody titers. African-American subjects had higher neutralizing antibody titers than Caucasians (1260mIU/mL vs. 740mIU/mL, p=7.10×10 <superscript>-13</superscript> ), and those titers remained statistically significant (p=1.68×10 <superscript>-09</superscript> ) after adjusting for age at enrollment and time since last vaccination. There were no statistically significant sex-specific differences in measles-induced neutralizing antibody titers in our study (p=0.375). Our data indicate a surprising lack of evidence for an association between GM and KM genotypes and measles-specific neutralizing antibody titers, despite the importance of these immune response genes.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Black or African American
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
Cohort Studies
Female
Genotype
Humans
Male
Measles virus immunology
Vaccination methods
Young Adult
Immunity, Humoral immunology
Immunoglobulin Gm Allotypes immunology
Immunoglobulin Km Allotypes immunology
Measles immunology
Measles prevention & control
Measles Vaccine immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 35
- Issue :
- 41
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 28274637
- Full Text :
- https://doi.org/10.1016/j.vaccine.2017.02.046