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Platelets and circulating CD34-positive cells as an indicator of the activity of the vicious cycle between hypertension and endothelial dysfunction in elderly Japanese men.
- Source :
-
Atherosclerosis [Atherosclerosis] 2017 Apr; Vol. 259, pp. 26-31. Date of Electronic Publication: 2017 Feb 24. - Publication Year :
- 2017
-
Abstract
- Background and Aims: The bi-directional association between hypertension and endothelial dysfunction (vicious cycle) is crucial for the development of cardiovascular disease. Since platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and the development of atherosclerosis), these two factors could act as an indicator for the activity of this vicious cycle.<br />Methods: We conducted a cross-sectional study of 580 Japanese men aged 60-69 years who underwent an annual health check-up. Since aggressive endothelial repair might cause consumptive reduction of circulating CD34-positive cells, subjects were stratified by circulating CD34-positive count (<1.01 cells/μL or ≥ 1.01 cells/μL).<br />Results: Platelet count is positively associated with hypertension among participants with a low CD34-positive cell count (multivariable-OR (odds ratio) for hypertension of 1 standard deviation (SD) increments in platelets (5.24 × 10 <superscript>4</superscript> /μL) = 1.47 (1.12, 1.91)), but not among participants with a high CD34-positive cell count (multivariable-OR = 0.91 (0.71, 1.18)). We also found that platelet count is positively associated with carotid intima-media thickness related to endothelial dysfunction among hypertensive participants with a low CD34-positive cell count (standardized parameter estimate (β) = 0.26, p = 0.008), but not with a high CD34-positive cell count (β = 0.11, p = 0.234).<br />Conclusions: Our results indicate that the number of platelets and circulating CD34-positive cells acts as an indicator of the activity of the vicious cycle that exists between hypertension and endothelial dysfunction in elderly Japanese men.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Age Factors
Aged
Aging blood
Biomarkers blood
Carotid Artery Diseases diagnosis
Carotid Artery Diseases physiopathology
Carotid Intima-Media Thickness
Endothelium, Vascular physiopathology
Humans
Hypertension diagnosis
Hypertension physiopathology
Japan
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Platelet Count
Risk Factors
Sex Factors
Antigens, CD34 blood
Blood Platelets metabolism
Carotid Artery Diseases blood
Endothelium, Vascular metabolism
Hypertension blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 259
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 28282559
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2017.02.016