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Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population.
- Source :
-
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2017 Apr; Vol. 118 (4), pp. 483-488.e1. Date of Electronic Publication: 2017 Mar 09. - Publication Year :
- 2017
-
Abstract
- Background: Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation. The role of TGF- β 1 single-nucleotide polymorphisms (SNPs) in allergic disease remains inconclusive.<br />Objective: To evaluate the effects of genetic variations in the TGF-β1 on allergy and helminths infections in children.<br />Methods: We tested for association among 4 TGF-β1 SNPs and allergic asthma, specific IgE, skin prick test result, and IL-10 production in 1,335 Brazilians. In addition, we analyzed the association with markers of helminth infection (parasite burden, anti-Ascaris IgE, and worm specific IgG4). The polymorphisms were genotyped using Taq Man probes.<br />Results: We found an association between rs1800470 (C allele) and atopic wheezing (odds ratio [OR], 0.60; 95% confidence interval [CI], 0.37-0.95) and markers of allergy (OR, 0.41; 95% CI, 0.22-0.79). In contrast, a positive association was observed between the haplotype ACCA and Trichuris trichiura infection (OR, 1.85; P = .003) and Ascaris lumbricoides infection (OR, 2.01; P < .001). This haplotype was also associated with increased IL-10 production (β = 50.7; P < .001).<br />Conclusion: Individuals with TGF-β1 polymorphisms have an increased susceptibility to helminth infections and a lower risk of developing allergy. These studies suggest that immune modulation of allergic disease results not only from environmental factors but also from genetic susceptibility and IL-10 production.<br /> (Copyright © 2017 American College of Allergy, Asthma & Immunology. All rights reserved.)
- Subjects :
- Alleles
Asthma epidemiology
Brazil epidemiology
Brazil ethnology
Child
Child, Preschool
Female
Gene Frequency
Genotype
Haplotypes
Helminthiasis epidemiology
Humans
Immunoglobulin E blood
Immunoglobulin E immunology
Interleukin-10 metabolism
Male
Odds Ratio
Polymorphism, Single Nucleotide
Skin Tests
Asthma etiology
Ethnicity
Genetic Predisposition to Disease
Helminthiasis etiology
Polymorphism, Genetic
Transforming Growth Factor beta1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1534-4436
- Volume :
- 118
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28284979
- Full Text :
- https://doi.org/10.1016/j.anai.2017.01.028