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Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation.
- Source :
-
Archives of dermatological research [Arch Dermatol Res] 2017 Jul; Vol. 309 (5), pp. 397-402. Date of Electronic Publication: 2017 Mar 16. - Publication Year :
- 2017
-
Abstract
- Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial. Our results confirmed that the expression of type Ι collagen in dermal fibroblast cells treated with palmitoyl-KVK-L-ascorbic acid (0.1-4 μg/mL) increased in a dose-dependent manner. In B16F1 cells, treatment with 20 μg/mL palmitoyl-KVK-L-ascorbic acid reduced the melanin content by approximately 20% compared to alpha-melanocyte stimulating hormone treatment. In the clinical trial, application of palmitoyl-KVK-L-ascorbic acid cream led to an improvement in skin roughness and lightness in 12 and 8 weeks, respectively. Our data show that palmitoyl-KVK-L-ascorbic acid is an effective anti-aging agent that reduces wrinkles and abnormal skin pigmentation.
Details
- Language :
- English
- ISSN :
- 1432-069X
- Volume :
- 309
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of dermatological research
- Publication Type :
- Academic Journal
- Accession number :
- 28303328
- Full Text :
- https://doi.org/10.1007/s00403-017-1731-6