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Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2017 Apr 05; Vol. 15 (14), pp. 3060-3068. - Publication Year :
- 2017
-
Abstract
- A novel and practical synthesis of 3-benzoylquinoxalin-2(1H)-ones from benzodiazepin-2-ones in two steps from commercially available starting materials is reported. The reaction was achieved in the presence of N-bromosuccinimide in DMSO which served both as a solvent and an oxidant. Significantly, the yet unknown ketone to alcohol fluorescence turn-on of benzoylquinoxalinones was unveiled through the preparation of a fluorescently labelled cholesterol conjugate.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 15
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28317989
- Full Text :
- https://doi.org/10.1039/c7ob00205j