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Adverse Events in Cancer Immunotherapy.
- Source :
-
Advances in experimental medicine and biology [Adv Exp Med Biol] 2017; Vol. 995, pp. 155-174. - Publication Year :
- 2017
-
Abstract
- Cancer immunotherapy has resulted in durable responses in patients with metastatic disease, unseen with traditional chemotherapy. Several therapies have been approved by the Food and Drug Administration for the treatment of various cancers, including: immune checkpoint inhibitors, cytokines - interleukin 2 (IL-2) and interferon alpha (IFN), and the cancer vaccine sipuleucel-T. These therapies upregulate the immune system to enhance antitumor responses. As a consequence, they can cause inflammatory and immune-related adverse events that can affect one or more organs, can be serious, and on occasion lifethreatening. The management of these adverse events is complex, and requires a multidisciplinary approach involving not only oncologists, but also other internal medicine specialists, to ensure prompt diagnosis and optimal management of these complications.
- Subjects :
- Animals
Humans
Immunotherapy methods
Molecular Targeted Therapy
Neoplasms immunology
Neoplasms metabolism
Neoplasms pathology
Patient Safety
Risk Assessment
Risk Factors
Treatment Outcome
Antineoplastic Agents adverse effects
Cancer Vaccines adverse effects
Immunotherapy adverse effects
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2598
- Volume :
- 995
- Database :
- MEDLINE
- Journal :
- Advances in experimental medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 28321817
- Full Text :
- https://doi.org/10.1007/978-3-319-53156-4_8