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Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample of suicide completers, attempters and controls.
- Source :
-
Journal of psychiatric research [J Psychiatr Res] 2017 Aug; Vol. 91, pp. 98-104. Date of Electronic Publication: 2017 Mar 10. - Publication Year :
- 2017
-
Abstract
- Several lines of evidence indicate that suicidal behaviour is partly heritable, with multiple genes implicated in its aetiology. We focused on nine genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) which we previously detected as differentially expressed in the cortex of suicide victims compared to controls. We investigated 84 variants within these genes in 495 suicidal subjects (299 completers and 196 attempters) and 1513 controls (109 post-mortem and 1404 healthy). We evaluated associations with: 1) suicidal phenotype; 2) possible endophenotypes for suicidal behaviour. Overall positive results did not survive the correction threshold. However, we found a nominally different distribution of EFEMP1 genotypes, alleles and haplotypes between suicidal subjects and controls, results that were partially replicated when we separately considered the subgroup of suicide completers and post-mortem controls. A weaker association emerged also for PTPRR. Both EFEMP1 and PTPRR genes were also related to possible endophenotypes for suicidal behaviour such as anger, depression-anxiety and fatigue. Because of the large number of analyses performed and the low significance values further replication are mandatory. Nevertheless, neurotrophic gene variants, in particular EFEMP1 and PTPRR, may have a role in the pathogenesis of suicidal behaviour.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Autopsy
Female
Genotype
Humans
Male
Middle Aged
Self-Injurious Behavior psychology
Suicidal Ideation
Surveys and Questionnaires
Extracellular Matrix Proteins genetics
Polymorphism, Single Nucleotide genetics
Receptor-Like Protein Tyrosine Phosphatases, Class 7 genetics
Self-Injurious Behavior genetics
Suicide psychology
Suicide, Attempted psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1379
- Volume :
- 91
- Database :
- MEDLINE
- Journal :
- Journal of psychiatric research
- Publication Type :
- Academic Journal
- Accession number :
- 28327445
- Full Text :
- https://doi.org/10.1016/j.jpsychires.2017.03.009