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Molecular Dynamics Validation of Crizotinib Resistance to ALK Mutations (L1196M and G1269A) and Identification of Specific Inhibitors.

Authors :
Nagasundaram N
Wilson Alphonse CR
Samuel Gnana PV
Rajaretinam RK
Source :
Journal of cellular biochemistry [J Cell Biochem] 2017 Oct; Vol. 118 (10), pp. 3462-3471. Date of Electronic Publication: 2017 May 18.
Publication Year :
2017

Abstract

Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) patients are mostly treated with ALK tyrosine kinase inhibitors (TKIs). Crizotinib is the first generation ALK inhibitor practiced as a primary chemo to combat cancer cells followed by second generation inhibitor ceritinib which are effective against crizotinib resistant ALK mutations. However, patients treated with these drugs invariably relapsed because of the development of new drug resistance mutations. In this study we explored the crizotinib resistance in the presence of ALK mutations L1196M and G1269A through molecular dynamics simulation studies. Further mutation specific inhibitors CID 71748211 and CID 71728095 were identified to potentially inhibit ALK with mutations L1196M and G1269A, respectively. This computational investigation in-sighted the molecular factors involved in crizotinib resistance which enhanced in the identification of new ALK drugs that brings individualized medicine to treat ALK positive NSCLC patients with specific mutations. J. Cell. Biochem. 118: 3462-3471, 2017. © 2017 Wiley Periodicals, Inc.<br /> (© 2017 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1097-4644
Volume :
118
Issue :
10
Database :
MEDLINE
Journal :
Journal of cellular biochemistry
Publication Type :
Academic Journal
Accession number :
28332225
Full Text :
https://doi.org/10.1002/jcb.26004