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[The influence of hypothyroidism on the conversion and binding of thyroid hormones in patients with end-stage renal disease].
- Source :
-
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego [Pol Merkur Lekarski] 2017 Mar 21; Vol. 42 (249), pp. 101-105. - Publication Year :
- 2017
-
Abstract
- Hypothyroidism in patients with renal failure (RF) causes many metabolic and clinical problems, and both these diseases can mutually exacerbate their disturbances.<br />Aim: The aim of this study was to evaluate the effect of hypothyroidism, and end-stage renal disease (ESRD) on conversion of thyroid hormones (TH) in patients with ESRD treated with chronic hemodialysis (HD).<br />Materials and Methods: The study was performed in 74 patients, including 41 women (K) and 33 men (M) aged 28-83 y.o. in 4 groups: G1 - 12 people with ESRD treated with HD and with newly diagnosed hypothyroidism without substitution (6 K and M 6) aged 66,83±12,90 y.o., G2 - 26 patients with ESRD treated with HD without hypothyroidism (10 F, 16 M) aged 58,85±15,52 y.o., G3 - 11 hypothyroid patients without RF (9 K, 2 M) aged 54,73±21,26 y.o., G4 - 25-persons from control group of healthy subjects (16 M, 9 M) aged 51,24±12,58 y.o. In all subjects the concentration of TSH and TH (T4, T3, fT4, TSH, FT3, rT3) were measured and values of conversion factors (T3/T4, FT3/ fT4, rT3/fT4 and rT3/fT3) and binding TH to protein factors (fT4/T4 and fT3/T3) were calculated.<br />Results: Lower concentration of T3 (p=0.012), fT3 (p<0.001) i fT4 (p=0.014) was found in patients without hypothyroidism than in healthy subjects. Renal failure with concomitant hypothyroidism intensify the disturbances of T4 to T3 conversion (p=0.034) and hypothyroidism with concomitant renal failure disrupts binding of T3 to proteins (p=0.001). FT3 to fT4 ratio in renal failure with concomitant hypothyroidism group was significantly lower than in each other group. rT3 concentrations were the highest in healthy subjects.<br />Conclusions: Concomitance of hypothyroidism and end-stage renal disease reduces the conversion of thyroxine to triiodothyronine, but does not increase the production of rT3. Hypothyroidism significantly increases the disorders of thyroid hormones in end-stage renal disease. There is decreased tendency to bind of thyroid hormone to protein in hypothyroidism in patients with end-stage renal disease.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Hypothyroidism blood
Hypothyroidism complications
Kidney Failure, Chronic blood
Kidney Failure, Chronic complications
Kidney Failure, Chronic therapy
Male
Middle Aged
Protein Binding
Renal Dialysis
Thyroid Hormones blood
Hypothyroidism metabolism
Kidney Failure, Chronic metabolism
Thyroid Hormones metabolism
Subjects
Details
- Language :
- Polish
- ISSN :
- 1426-9686
- Volume :
- 42
- Issue :
- 249
- Database :
- MEDLINE
- Journal :
- Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
- Publication Type :
- Academic Journal
- Accession number :
- 28333900