Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1.

Subjects

Subjects :

Apoptosis
Drug Resistance, Neoplasm drug effects
Humans
Hydrazines pharmacology
Leukemia, Lymphocytic, Chronic, B-Cell genetics
Triazoles pharmacology
Exportin 1 Protein
Chromosomes, Human, Pair 2
Drug Resistance, Neoplasm genetics
Gene Expression Regulation, Leukemic
Hydrazines therapeutic use
Karyopherins genetics
Leukemia, Lymphocytic, Chronic, B-Cell drug therapy
Receptors, Cytoplasmic and Nuclear genetics
Triazoles therapeutic use

Details

Language :

English

ISSN :

1476-5551

Volume :

31

Issue :

7

Database :

MEDLINE

Journal :

Leukemia

Publication Type :

Report

Accession number :

28344316

Full Text :

https://doi.org/10.1038/leu.2017.100