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Protective Effect of Selenium on Aflatoxin B1-Induced Testicular Toxicity in Mice.
- Source :
-
Biological trace element research [Biol Trace Elem Res] 2017 Dec; Vol. 180 (2), pp. 233-238. Date of Electronic Publication: 2017 Mar 27. - Publication Year :
- 2017
-
Abstract
- Aflatoxins have been considered as one of the major risk factors of male infertility, and aflatoxin B1 (AFB1) is the most highly toxic and prevalent member of the aflatoxins family. Selenium (Se), an essential nutritional trace mineral for normal testicular development and male fertility, has received extensive intensive on protective effects of male reproductive system due to its potential antioxidant and activating testosterone synthesis. To investigate the protective effect of Se on AFB1-induced testicular toxicity, the mice were orally administered with AFB1 (0.75 mg/kg) and Se (0.2 mg/kg or 0.4 mg/kg) for 45 days. We found that that Se elevated testes index, sperm functional parameters (concentration, malformation, and motility), and the level of serum testosterone in AFB1-exposed mice. Moreover, our results showed that Se attenuated the AFB1-induced oxidative stress and the reduction of testicular testosterone synthesis enzyme protein expression such as steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage (P450scc), and 17β-hydroxysteroid dehydrogenase (17β-HSD) in AFB1-exposed mice. These results demonstrated that Se conferred protection against AFB1-induced testicular toxicity and can be attributed to its antioxidant and increased testosterone level by stimulating protein expression of StAR and testosterone synthetic enzymes.
- Subjects :
- 17-Hydroxysteroid Dehydrogenases antagonists & inhibitors
17-Hydroxysteroid Dehydrogenases chemistry
17-Hydroxysteroid Dehydrogenases metabolism
Aflatoxin B1 toxicity
Animals
Animals, Outbred Strains
Antioxidants therapeutic use
Biomarkers blood
Biomarkers metabolism
Carcinogens, Environmental chemistry
Carcinogens, Environmental toxicity
Cholesterol Side-Chain Cleavage Enzyme antagonists & inhibitors
Cholesterol Side-Chain Cleavage Enzyme chemistry
Cholesterol Side-Chain Cleavage Enzyme metabolism
Food Contamination
Foodborne Diseases etiology
Foodborne Diseases prevention & control
Infertility, Male blood
Infertility, Male chemically induced
Infertility, Male metabolism
Male
Mice
Phosphoproteins agonists
Phosphoproteins antagonists & inhibitors
Phosphoproteins metabolism
Protective Agents administration & dosage
Selenium administration & dosage
Semen Analysis
Sodium Selenite administration & dosage
Testis metabolism
Testosterone biosynthesis
Testosterone blood
Aflatoxin B1 antagonists & inhibitors
Dietary Supplements
Infertility, Male prevention & control
Oxidative Stress drug effects
Protective Agents therapeutic use
Selenium therapeutic use
Testis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0720
- Volume :
- 180
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biological trace element research
- Publication Type :
- Academic Journal
- Accession number :
- 28349382
- Full Text :
- https://doi.org/10.1007/s12011-017-0997-z