Back to Search
Start Over
Strain-specific estimation of epidemic success provides insights into the transmission dynamics of tuberculosis.
- Source :
-
Scientific reports [Sci Rep] 2017 Mar 28; Vol. 7, pp. 45326. Date of Electronic Publication: 2017 Mar 28. - Publication Year :
- 2017
-
Abstract
- The transmission dynamics of tuberculosis involves complex interactions of socio-economic and, possibly, microbiological factors. We describe an analytical framework to infer factors of epidemic success based on the joint analysis of epidemiological, clinical and pathogen genetic data. We derive isolate-specific, genetic distance-based estimates of epidemic success, and we represent success-related time-dependent concepts, namely epidemicity and endemicity, by restricting analysis to specific time scales. The method is applied to analyze a surveillance-based cohort of 1,641 tuberculosis patients with minisatellite-based isolate genotypes. Known predictors of isolate endemicity (older age, native status) and epidemicity (younger age, sputum smear positivity) were identified with high confidence (P < 0.001). Long-term epidemic success also correlated with the ability of Euro-American and Beijing MTBC lineages to cause active pulmonary infection, independent of patient age and country of origin. Our results demonstrate how important insights into the transmission dynamics of tuberculosis can be gained from active surveillance data.
- Subjects :
- Adult
Aged
Female
Genetic Variation
Genotype
Haplotypes
Humans
Male
Middle Aged
Minisatellite Repeats genetics
Mycobacterium tuberculosis isolation & purification
Risk Factors
Sputum microbiology
Tuberculosis epidemiology
Tuberculosis microbiology
Tuberculosis transmission
Mycobacterium tuberculosis genetics
Tuberculosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28349973
- Full Text :
- https://doi.org/10.1038/srep45326