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Efficacy of Botulinum Toxin B Injection for Raynaud's Phenomenon and Digital Ulcers in Patients with Systemic Sclerosis.
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2017 Jul 06; Vol. 97 (7), pp. 843-850. - Publication Year :
- 2017
-
Abstract
- The efficacy and safety of botulinum toxin B (BTX-B) for treatment of Raynaud's phenomenon and digital ulcers in patients with systemic sclerosis was assessed. A total of 45 patients with systemic sclerosis who had Raynaud's phenomenon were blinded and divided randomly into 4 groups: a no-treatment control group, and 3 treatment groups, using 250, 1,000 or 2,000 international units (U) of BTX-B injections in the hand with more severe symptoms. Four weeks after injection, pain/numbness visual analogue scale scores and Raynaud's score in the groups treated with 1,000 and 2,000 U BTX-B were significantly lower than in the control group and the group treated with 250 U BTX-B. These beneficial effects were sustained until 16 weeks after the single injection. At 4 weeks after injection skin temperature recovery in the group treated with 2,000 U BTX-B was significantly improved. The numbers of digital ulcers in the groups treated with 1,000 and 2,000 U BTX-B were significantly lower than in the control group. In conclusion, 1,000 and 2,000 U BTX-B injections significantly suppressed the activity of Raynaud's phenomenon and digital ulcers in patients with SSc without serious adverse events.
- Subjects :
- Acetylcholine Release Inhibitors adverse effects
Aged
Botulinum Toxins, Type A adverse effects
Female
Humans
Injections
Japan
Male
Middle Aged
Prospective Studies
Raynaud Disease diagnosis
Raynaud Disease etiology
Raynaud Disease physiopathology
Single-Blind Method
Skin Temperature drug effects
Skin Ulcer diagnosis
Skin Ulcer etiology
Skin Ulcer physiopathology
Time Factors
Treatment Outcome
Wound Healing drug effects
Acetylcholine Release Inhibitors administration & dosage
Botulinum Toxins, Type A administration & dosage
Raynaud Disease drug therapy
Scleroderma, Systemic complications
Skin Ulcer drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2057
- Volume :
- 97
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 28358168
- Full Text :
- https://doi.org/10.2340/00015555-2665