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Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy.
- Source :
-
Sleep [Sleep] 2017 Jan 01; Vol. 40 (1). - Publication Year :
- 2017
-
Abstract
- Objectives: To investigate whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration are altered in narcolepsy in order to evaluate whether the hypocretin deficiency and abnormal sleep-wake pattern in narcolepsy leads to neurodegeneration.<br />Methods: Twenty-one patients with central hypersomnia (10 type 1 narcolepsy, 5 type 2 narcolepsy, and 6 idiopathic hypersomnia cases), aged 33 years on average and with a disease duration of 2-29 years, and 12 healthy controls underwent CSF analyses of the levels of β-amyloid, total tau protein (T-tau), phosphorylated tau protein (P-tau181), α-synuclein, neurofilament light chain (NF-L), and chitinase 3-like protein-1 (CHI3L1).<br />Results: Levels of β-amyloid were lower in patients with type 1 narcolepsy (375.4 ± 143.5 pg/mL) and type 2 narcolepsy (455.9 ± 65.0 pg/mL) compared to controls (697.9 ± 167.3 pg/mL, p < .05). Furthermore, in patients with type 1 narcolepsy, levels of T-tau (79.0 ± 27.5 pg/mL) and P-tau181 (19.1 ± 4.3 pg/mL) were lower than in controls (162.2 ± 49.9 pg/mL and 33.8 ± 9.2 pg/mL, p < .05). Levels of α-synuclein, NF-L, and CHI3L1 in CSF from narcolepsy patients were similar to those of healthy individuals.<br />Conclusion: Six CSF biomarkers of neurodegeneration were decreased or normal in narcolepsy indicating that taupathy, synucleinopathy, and immunopathy are not prevalent in narcolepsy patients with a disease duration of 2-29 years. Lower CSF levels of β-amyloid, T-tau protein, and P-tau181 in narcolepsy may indicate that hypocretin deficiency and an abnormal sleep-wake pattern alter the turnover of these proteins in the central nervous system.<br /> (© Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.)
- Subjects :
- Adult
Amyloid beta-Peptides cerebrospinal fluid
Case-Control Studies
Chitinase-3-Like Protein 1 cerebrospinal fluid
Female
Humans
Idiopathic Hypersomnia cerebrospinal fluid
Male
Neurofilament Proteins cerebrospinal fluid
Orexins cerebrospinal fluid
alpha-Synuclein cerebrospinal fluid
tau Proteins cerebrospinal fluid
Biomarkers cerebrospinal fluid
Narcolepsy cerebrospinal fluid
Neurodegenerative Diseases cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1550-9109
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Sleep
- Publication Type :
- Academic Journal
- Accession number :
- 28364448
- Full Text :
- https://doi.org/10.1093/sleep/zsw006