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Human B and T lymphocytes convert leukotriene A4 into leukotriene B4.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1988 May 31; Vol. 153 (1), pp. 203-8. - Publication Year :
- 1988
-
Abstract
- Incubation of human tonsillar B lymphocytes and peripheral blood T lymphocytes with leukotriene A4 led to the formation of leukotriene B4. The purity of these cell suspensions was more than 99%, containing less than 0.5% monocytes. Incubation of purified B or T lymphocytes with the calcium ionophore A23187 did not lead to the formation of any detectable amounts of leukotrienes. Several established cell lines of B and T lymphocytic origin were also found to convert leukotriene A4 into leukotriene B4, showing that monoclonal lymphocytic cells possess leukotriene A4 hydrolase activity.
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 153
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 2837199
- Full Text :
- https://doi.org/10.1016/s0006-291x(88)81209-9