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Stress-related immune suppression: health implications.
- Source :
-
Brain, behavior, and immunity [Brain Behav Immun] 1987 Mar; Vol. 1 (1), pp. 7-20. - Publication Year :
- 1987
-
Abstract
- This study used a year-long prospective design to assess linkages among distress, immunity, and illness. Serial blood samples were collected from 40 first-year medical students at the first, third, and fifth examination periods, as well as 1 month before each. There were significant decrements in the production of gamma-interferon by concanavalin A-stimulated lymphocytes obtained at the time of examinations. Antibody titers to Epstein-Barr virus (EBV) increased during examination periods, suggesting reactivation of latent EBV and therefore poorer cellular immune control of latent virus. We obtained data that suggest that T-cell killing by memory T lymphocytes of EBV transformed autologous B lymphocytes also declined during examination periods. The activity of a lymphokine, leukocyte migration inhibition factor, normally suppressed during recrudescence of herpes simplex virus type 2 infections, was altered during examination periods and an increase in both plasma and intracellular levels of cyclic AMP associated with examination stress was observed. An increase in the incidence of self-reported symptoms of infectious illness was also associated with examination periods. The data support the linkage between stress-related immunosuppression and health.
- Subjects :
- Adult
Antibodies, Viral biosynthesis
Antigens, Viral immunology
Cyclic AMP blood
Cytotoxicity, Immunologic
Educational Measurement
Female
Herpesvirus 4, Human immunology
Humans
Interferon-gamma deficiency
Leukocyte Migration-Inhibitory Factors analysis
Lymphocyte Activation
Male
Nutritional Status
Prospective Studies
Self-Assessment
Students, Medical psychology
Virus Activation
Capsid Proteins
Immunologic Deficiency Syndromes etiology
Stress, Physiological complications
Subjects
Details
- Language :
- English
- ISSN :
- 0889-1591
- Volume :
- 1
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain, behavior, and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 2837297
- Full Text :
- https://doi.org/10.1016/0889-1591(87)90002-x