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Multifunctional Nanosystem for Synergistic Tumor Therapy Delivered by Two-Dimensional MoS 2 .
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2017 Apr 26; Vol. 9 (16), pp. 13965-13975. Date of Electronic Publication: 2017 Apr 13. - Publication Year :
- 2017
-
Abstract
- A multifunctional nanosystem based on two-dimensional molybdenum disulfide (MoS <subscript>2</subscript> ) was developed for synergistic tumor therapy. MoS <subscript>2</subscript> was stabilized with lipoic acid (LA)-modified poly(ethylene glycol) and modified with a pH-responsive charge-convertible peptide (LA-K <subscript>11</subscript> (DMA)). Then, a positively charged photosensitizer, toluidine blue O (TBO), was loaded on MoS <subscript>2</subscript> via physical absorption. The negatively charged LA-K <subscript>11</subscript> (DMA) peptide was converted into a positively charged one under acidic conditions. Charge conversion of the peptide could reduce the binding force between positively charged TBO and MoS <subscript>2</subscript> , leading to TBO release. Furthermore, the positively charged nanosystem was easily endocytosed by cells. Photo-induced hyperthermia of MoS <subscript>2</subscript> in the tumor areas could promote TBO release and exhibited photothermal therapy. In vitro and in vivo results demonstrated that fluorescence and photo-induced reactive oxygen species (ROS) generation of TBO were severely decreased by MoS <subscript>2</subscript> under normal conditions. While in the acidic condition, the pH-responsive nanosystem exhibited a highly specific and efficient antitumor effect with TBO release and photo-induced ROS generation, suggesting to be a promising accessory for synergistic tumor therapy.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 9
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 28378999
- Full Text :
- https://doi.org/10.1021/acsami.7b03276