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High expression of IMPDH2 is associated with aggressive features and poor prognosis of primary nasopharyngeal carcinoma.
- Source :
-
Scientific reports [Sci Rep] 2017 Apr 07; Vol. 7 (1), pp. 745. Date of Electronic Publication: 2017 Apr 07. - Publication Year :
- 2017
-
Abstract
- Inosine monophosphate dehydrogenase type II (IMPDH2) has been shown to play critical roles in the development and progression of several human cancers. However, little is known about IMPDH2 expression and its clinical significance in nasopharyngeal carcinoma (NPC). Western blotting, qRT-PCR and immunohistochemistry were employed to evaluate IMPDH2 expression in NPC cell lines and tissues. In our study, elevated expression of IMPDH2 was observed at both the protein and mRNA levels in NPC cell lines than in NPEC2 Bmi-1. IMPDH2 protein expression was markedly higher in NPC tissues than in adjacent non-tumorous tissues. Moreover, IMPDH2 expression in NPC correlated with several clinicopathological parameters, including T classification (P = 0.023), TNM stage (P = 0.020), distant metastasis (P = 0.001) and death (P = 0.002). Further Cox regression analysis suggested that IMPDH2 expression was an independent prognostic factor for overall survival (P = 0.001) and disease-free survival (P < 0.001). In addition, stratified survival analysis showed that high expression of IMPDH2 could be a prognostic factor for NPC patients with TNM stage I/II (OS: P = 0.012; DMFS: P = 0.007), TNM stage III/IV (OS: P = 0.028; DMFS: P = 0.020). Our study demonstrates IMPDH2 may be served as an independent prognostic biomarker for NPC patients, in which high IMPDH expression suggests poor prognosis of NPC patients.
- Subjects :
- Adult
Carcinoma pathology
Cell Line, Tumor
Female
Humans
IMP Dehydrogenase metabolism
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms pathology
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Proportional Hazards Models
ROC Curve
Young Adult
Biomarkers, Tumor
Carcinoma genetics
Carcinoma mortality
Gene Expression
IMP Dehydrogenase genetics
Nasopharyngeal Neoplasms genetics
Nasopharyngeal Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28389646
- Full Text :
- https://doi.org/10.1038/s41598-017-00887-1