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Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors.
- Source :
-
Neuroscience bulletin [Neurosci Bull] 2017 Aug; Vol. 33 (4), pp. 365-372. Date of Electronic Publication: 2017 Apr 07. - Publication Year :
- 2017
-
Abstract
- Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion, and cognition. However, the role of orexin in somatic motor control is still little known. Here, using whole-cell patch clamp recording and immunostaining, we investigated the effect and the underlying receptor mechanism of orexin-A on neurons in the globus pallidus internus (GPi), a critical structure in the basal ganglia and an effective target for deep brain stimulation therapy. Our results showed that orexin-A induced direct postsynaptic excitation of GPi neurons in a concentration-dependent manner. The orexin-A-induced excitation was mediated via co-activation of both OX1 and OX2 receptors. Furthermore, the immunostaining results showed that OX1 and OX2 receptors were co-localized in the same GPi neurons. These results suggest that the central orexinergic system actively modulates the motor functions of the basal ganglia via direct innervation on GPi neurons and presumably participates in somatic-non-somatic integration.
- Subjects :
- Action Potentials drug effects
Action Potentials physiology
Animals
Dose-Response Relationship, Drug
Electric Stimulation
Excitatory Amino Acid Antagonists pharmacology
Female
In Vitro Techniques
Isoquinolines pharmacology
Male
Orexin Receptors agonists
Patch-Clamp Techniques
Pyridazines pharmacology
Pyridines pharmacology
Quinoxalines pharmacology
Rats
Rats, Sprague-Dawley
Sodium Channel Blockers pharmacology
Tetrodotoxin pharmacology
Globus Pallidus cytology
Interneurons drug effects
Orexin Receptors metabolism
Orexins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1995-8218
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuroscience bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 28389870
- Full Text :
- https://doi.org/10.1007/s12264-017-0127-0