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SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis.
- Source :
-
Developmental cell [Dev Cell] 2017 Apr 10; Vol. 41 (1), pp. 47-58.e4. - Publication Year :
- 2017
-
Abstract
- The plant hormones brassinosteroids (BRs) participate in light-mediated regulation of plant growth, although the underlying mechanisms are far from being fully understood. In addition, the function of the core transcription factor in the BR signaling pathway, BRI1-EMS-SUPPRESSOR 1 (BES1), largely depends on its phosphorylation status and its protein stability, but the regulation of BES1 is not well understood. Here, we report that SINA of Arabidopsis thaliana (SINATs) specifically interact with dephosphorylated BES1 and mediate its ubiquitination and degradation. Our genetic data demonstrated that SINATs inhibit BR signaling in a BES1-dependent manner. Interestingly, we found that the protein levels of SINATs were decreased in the dark and increased in the light, which changed BES1 protein levels accordingly. Thus, our study not only uncovered a new mechanism of BES1 degradation but also provides significant insights into how light conditionally regulates plant growth through controlling accumulation of different forms of BES1.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Arabidopsis drug effects
Arabidopsis growth & development
Arabidopsis Proteins chemistry
DNA-Binding Proteins
Gene Knockdown Techniques
Models, Biological
Protein Binding drug effects
Protein Binding radiation effects
Protein Stability drug effects
Protein Stability radiation effects
Proteolysis drug effects
Proteolysis radiation effects
RING Finger Domains
Signal Transduction drug effects
Signal Transduction radiation effects
Ubiquitination drug effects
Ubiquitination radiation effects
Arabidopsis metabolism
Arabidopsis radiation effects
Arabidopsis Proteins metabolism
Brassinosteroids pharmacology
Light
Nuclear Proteins metabolism
Ubiquitin-Protein Ligases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1551
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 28399399
- Full Text :
- https://doi.org/10.1016/j.devcel.2017.03.014