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Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
- Source :
-
Cancer cell [Cancer Cell] 2017 Apr 10; Vol. 31 (4), pp. 474-475. - Publication Year :
- 2017
-
Abstract
- Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N <superscript>6</superscript> -methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 28399407
- Full Text :
- https://doi.org/10.1016/j.ccell.2017.03.010