Back to Search
Start Over
High-dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow-up study.
- Source :
-
Annals of clinical biochemistry [Ann Clin Biochem] 2018 Mar; Vol. 55 (2), pp. 227-235. Date of Electronic Publication: 2017 Sep 06. - Publication Year :
- 2018
-
Abstract
- Background Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here, we explored the effects of high-dose vitamin D supplementation on cardio-metabolic risk factors. Methods We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurements were obtained at baseline and after supplementation with high-dose vitamin D. All individuals took a capsule of 50,000 IU vitamin D/week for nine weeks. The study was completed by 940 participants. Results The prevalence of vitamin D deficiency was 90% at baseline, reducing to 16.3% after vitamin D supplementation. Vitamin supplementation was associated with a significant increase in serum concentrations of 25 (OH) vitamin D and calcium. There were significant reductions in diastolic blood pressure, heart rate, waist circumference and serum fasting blood glucose, total- and low-density lipoprotein-cholesterol after the nine-week period on vitamin D treatment, but no significant effects were observed on body mass index, systolic blood pressure or serum high-density lipoprotein cholesterol and triglyceride. Conclusion Vitamin D supplementation had beneficial effects on cardio-metabolic profile in adolescent girls.
- Subjects :
- Adolescent
Blood Glucose metabolism
Blood Pressure
Body Mass Index
Calcium blood
Child
Cholesterol blood
Dose-Response Relationship, Drug
Female
Heart Rate
Humans
Iran
Risk Factors
Triglycerides blood
Vitamin D analogs & derivatives
Vitamin D blood
Vitamin D Deficiency drug therapy
Waist Circumference
Cardiovascular Diseases prevention & control
Dietary Supplements
Metabolic Syndrome prevention & control
Vitamin D administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1758-1001
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of clinical biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28406313
- Full Text :
- https://doi.org/10.1177/0004563217707784