Guaianolide sesquiterpenoids from Ainsliaea yunnanensis.

Authors :: Fang X
Xu XK
Wang GW
Zeng RT
Tian XH
Shi ZR
Zhuo ZG
Shen YH
Zhang WD
Source :: Phytochemistry [Phytochemistry] 2017 Jul; Vol. 139, pp. 47-55. Date of Electronic Publication: 2017 Apr 12.
Publication Year :: 2017
Abstract: Six previously undescribed C <subscript>17</subscript> -guaianolides, a previously undescribed guaianolide alkaloid, and two previously undescribed guaianolides as well as 10 known guaianolides were obtained from an ethanol extract of Ainsliaea yunnanensis Franch. The chemical structures of all previously reported sesquiterpenoids were determined by extensive NMR spectroscopic analysis in combination with a modified Mosher's method. All isolates were in vitro screened for inhibitory effect against nitric oxide release in RAW 264.7 macrophages stimulated by LPS. Zaluzanin C remarkably inhibited the production of nitric oxide with an IC <subscript>50</subscript> value of 6.54 μM.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)